147660 Zip
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Interferons ( e.g., 147660) affect cellular functions by altering the expression of a number of specific genes. Bange et al. (1994) reported a human cDNA, designated IFP35 by them (interferon-inducible protein of 35 kD), which they cloned from interferon-gamma (147570)-induced HeLa cell mRNA screened by differential hybridization. The cDNA encodes a 282-amino acid predicted protein containing a leucine zipper motif at the amino terminus. Unlike most other leucine zipper proteins, IFP35 lacks a basic domain associated with DNA binding. Bange et al. (1994) found that in vitro translation of IFP35 mRNA resulted in the synthesis of a 35-kD protein. Northern blots showed that the 1.4-kb IFP35 mRNA occurs in fibroblasts, macrophages, and epithelial cells following interferon treatment. Western blots indicated that the IFP35 gene product can form homodimers and that there was increased nuclear localization following interferon treatment. 781b155fdc